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DEPARTMENT OF BIOTECHNOLOGY
All India Institute of Medical Sciences (AIIMS),
Ansari Nagar, New Delhi-110029, India

Dr. Vikram Saini


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Primary Affiliation:

Associate Professor,
Department of Biotechnology,
All India Institute of Medical Sciences,
Ansari Nagar,
New Delhi-110029


Secondary Affiliation:

Biosafety Level-3 Laboratory (BSL-3),
Centralized Core Research Facility (CCRF),
All India Institute of Medical Sciences,
Ansari Nagar, New Delhi-110029
Link to CCRF


Email ID: vikram@aiims.edu


Phone(O): +91-11-26594994


Personal Web-Page: http://vikramjind.wixsite.com/vikramsaini


Lab Website: Dr. Vikram Saini


Research Interest:
Metabolism and bioenergetics of Infectious diseases, Redox Biology, Mycobacterial infections including HIV-TB co-infections, Nutrition and Virulence, Genomics and pathogenomics, Gaseous signaling and environmental risk factors for infections, Drug discovery and mechanisms of drug resistance.


Select Publications:

  1. Kumar A, Negi S, Choudhary T, Mutreja V, S Sunaina, Sahoo SC, Singh A, Mehta SK, Kataria R, Saini V (2023). A highly sensitive and specific luminescent MOF determines nitric oxide production and quantifies hydrogen sulfide-mediated inhibition of nitric oxide in living cells. Microchimica Acta. PMID: 36897440

  2. *Saini V, Kalra P, Sharma M, Rai C, Saini Vikas, Gautam K, Bhattacharya S, Mani S, Saini K, Kumar S (2021). A cold chain independent specimen collection and transport medium improves diagnostic sensitivity, and minimizes biosafety challenges Covid19 molecular diagnosis. Microbiology Spectrum. 9, e01108-21 (2021) Doi: 10.1128/Spectrum.01108-21 $Patent filed. Research Highlight in Nature India: Microbial transport medium improves COVID-19 diagnostic. https://www.nature.com/articles/d44151-022-00003-x
    PMID: 34878310

  3. Kumar P, Saini K, *Saini V, *Mitchell T (2021). Oxalate Suppresses macrophage immunometabolism and anti-bacterial response to uropathogenic E. coli (UPEC) infection. Frontiers in Immunology. Vol 12, Article 694865. https://doi.org/10.3389/fimmu.2021.694865.
    PMID: 34745086

  4. Saini, V, Chinta, K.C., Reddy, V.P. et al. Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis. Nature Communications.(2020) doi:10.1038/s41467-019-14132-y
    This noxious gas aggravates TB
    PMID: 31992699

  5. Chinta K, Rahman A, Saini V, Glasgow J, Reddy VP et al. (2019) Microanatomic distribution of myeloid Heme Oxygenase-1 protects against free radical-mediated immunopathology in human tuberculosis. Cell Reports, 25 (7), 1938-1952. e5. (Cover page article).
    PMID: 30428359

  6. Gupta P, Kaur N, Saini V, Bala M, Sherawat S, Gupta S, Dua A, Kumar V, Dutt V, Injeti Elisha, Mittal A. (2019) Cinnamaldehyde regulates H2O 2‐induced skeletal muscle atrophy by ameliorating the proteolytic and antioxidant defense systems. Journal of Cellular Physiology, 234 (5), 6194-6208.
    PMID: 30317570

  7. Patel M, Yarlagadda V, Adedoyin O, Saini V, Oreoluwa D, Holmes R, Mitchell T. (2018) Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell line. Redox Biology. Vol. 15, 207-215.
    PMID: 29272854

  8. Dutt V, Saini V, Gupta P, Kaur N, Bala M, Gujar R, Grewal A, Gupta S, Dua A, Mittal A (2018). S-allyl cysteine inhibits TNF alpha induced skeletal muscle wasting through suppressing proteolysis and expression of inflammatory molecules. Biochim Biophys Acta. (Gen Subjects); Vol. 1862 (4): 895-906.
    PMID: 29288771

  9. Saini V,Cumming BM, Guidry L, Lamprecht D, Adamson JH, Reddy VP, Chinta KC, Mazorodze J, Glasgow JN, Richard-Greenblatt M, Gomez-Velasco A, Bach H, Av-Gay Y, Eoh H, Rhee K, Steyn AJC (2016). Ergothioneine maintains redox and bioenergetichomeostasis essential for drug susceptibility and virulence of Mycobacterium tuberculosis. Cell Reports. Vol.14, 1-14.
    PMID: 26774486

  10. Saini V, Raghuvanshi S, Ahmed N, Khurana JP, Hasnain SE, Tyagi Akhilesh K, Tyagi Anil K (2012). Massive gene acquisitions in Mycobacterium indicus pranii provide a perspective on mycobacterial evolution.Nucleic Acids Res. doi: 10.1093/nar/gks793.Vol. 40 (21) 10832-10850.
    PMID: 22965120

    This is the first new bacterial species completely sequenced in India. Selected as a breakthrough article by NAR editorial board representing the top 5% of studies in terms of originality, significance and scientific excellence.

    Commentary at Nature: 'Mosaic genome' holds clue to TB, leprosy vaccines

  11. Saini V, Farhana A, Glasgow JN, Steyn AJC (2012). Iron sulfur cluster proteins and microbial regulation: Implications for understanding tuberculosis.
    Current Opinion in Chemical Biology. Vol. 16 (1-2), 45-53.
    PMID: 22483328


  12. I would be happy to discuss and sponsor self-motivated, hard-working and bright candidates applying for Post-doctoral fellowships/scientist positions for various funding agencies like DBT/DST and ICMR. Interested candidates should contact by email along with a 1-page write-up, CV and 3 references.





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